The Fisher Center for Alzheimer’s Research Foundation is an organization that provides millions of dollars for novel Alzheimer’s research primarily conducted by the late Nobel Laureate Dr. Paul Greengard and his team of over 45 internationally renowned scientists at the Fisher Center lab at The Rockefeller University, plus other leading research institutes around the world.
The Fisher Center is a nexus for Alzheimer’s disease research at Rockefeller. Its scientists work to expand and accelerate Alzheimer’s research and lay the foundation for new treatment strategies. In particular, the Fisher Center’s investigations build on research that explores various aspects of the disease including:
1) the processing of amyloid precursor protein (APP) that contributes to amyloid plaque formation;
2) the regulation of presenilin1, one of the two major enzymes involved in the processing of APP;
3) the identification and characterization of genomic differences between nerve cells that are vulnerable and those that are resistant to the disease;
4) the evaluation of the importance of microglia in the disease; and
5) attempts to create in vitro stem cells (iPSCs) corresponding to the nerve cells that are most vulnerable in the disease.